Vet News – Small Animal News

Vet NewsOur Small Animal News editor, Harriet tackles the fascinating and important topic of rabies and the Pet Travel Scheme in this month’s installment of Vet News.

 

 

 

SMALL ANIMALS:

Rabies & The Pet Travel Scheme

Harriet Woodhall (Vet News Small Animal News Editor)

Rabies has been frequently in the news over the past couple of months due to increasing concerns that it could enter the UK and due to the presence of World Rabies Day on 28th September.  There have been several cases of rabies in the Netherlands and other EU countries recently that have led to increased Government pressure to review UK quarantine laws that were previously relaxed to save pet owners money.

Dog being vaccinated against rabiesRabies is a fatal disease that can potentially affect all mammals, even humans. Due to the variable incubation period and ranging characteristics, it is often difficult to diagnose and predict the spread of the disease. Rabies has a wide range of clinical signs; meaning it has to be confirmed in a laboratory; however typical signs include sudden behavioural changes and progressive paralysis leading to death, if without treatment. The disease is mainly transmitted via saliva from a bite of an infected animal; dogs being the source of 99% of human rabies deaths.

Under the Pet Travel Scheme (PETS) dogs, cats and ferrets are allowed to enter the UK without being put in quarantine, provided they have a microchip, rabies vaccination 21 days before travelling and a pet passport; dogs also need tapeworm treatment. If the requirements are not met, the animal is then put into quarantine on arrival into the UK. Only once the requirements of the PETS scheme are met can the animal be released.

A blood test and a wait of 6 months following vaccination was previously needed to enter the UK from the EU or approved countries; this was relaxed in January 2012: blood tests are no longer needed and the wait before entering is now only 21 days. The relaxed wait could be seen as a risk, seeing as the rabies incubation period is so variable and can often be longer than 21 days.

rabies, dangers, posterOne of the biggest concerns is the increasing numbers of smuggled dogs and puppies entering the UK with forged passports, often without vaccination or vaccination at a too young age. It is thought that since regulation changes, people are less concerned about being caught due to the shorter quarantine time. This is a particularly big problem when the dog’s origin is unknown, as rabies is still endemic in parts of the world. Many vets are now suggesting that quarantine regulations are not strict enough, and are warning of the increased risk of rabies entering the UK. BVA President, Robin Hargreaves also stated that this increase and the case in the Netherlands should “be a serious wake-up call to potential pet owners who must always ask about the animal’s background and ask to see it with its mother”.

Government officials state that the risk of rabies entering the UK is still very low, but several animal welfare charities are still concerned that they are putting their staff at risk, now suggesting that staff themselves are vaccinated against the disease.

 

References:

http://www.mrcvs.co.uk/en/news-story.php?id=10839

http://www.bbc.co.uk/news/uk-24569593

https://www.gov.uk/take-pet-abroad/overview

http://www.defra.gov.uk/animal-diseases/a-z/rabies/

 

Picture Credits:

http://www.theguardian.com/global-development/2011/jul/18/eliminate-rabies-philippines

http://blog.wellcomelibrary.org/2012/08/item-of-the-month-august-2012-british-rabies-posters-from-the-1970s/

Vet News – Exotic News

Vet NewsOur Exotics Editor, Charlotte Hitch, discusses the use of Hormone Implants in Pet Ferrets with Adrenal Disease in this month’s installment of Vet News.

EXOTICS:

Hormone Implants for Pet Ferrets with Adrenal Disease

Charlotte Hitch (Vet News Exotics Editor)

Hyperadrenocorticism is arguably one of the most serious and prevalent diseases in pet ferrets in the USA and United Kingdom. There is a particularly high rate of incidence in neutered individuals; studies show that 50-75% of neutered ferrets develop the condition at some point in their lives. Although the prognoses may differ depending on how early in its development intervention occurs, the condition can potentially be life threatening in some cases if inflamed tissue causes anuria. The animal is then unable to remove waste and toxins from its body through urination.

Neutering the animal is considered to be one of the main causes of the onset of the disease, aside from excessive artificial light exposure and genetic predisposition. In the endocrine system, hormones work antagonistically against each other, and the presence of high levels of one hormone in the blood can stimulate the release of a different hormone to counteract the effects of the first. After neutering, there is no negative feedback from the gonads to the pituitary gland, so the pituitary gland continually releases a hormone called Gonadotrophin Releasing Hormone (GnRH) which in turn stimulates the overproduction of gonadotrophins (sex steroids) from the adrenal glands, situated beside each kidney.

Two ferretsOne hormone produced in great quantities is Luteinizing Hormone (LH), which stimulates ovulation. The gonads are no longer present to respond to high blood LH levels, so negative feedback does not occur and the levels continue to rise in an unregulated manner. Hyperplasia occurs in the adrenal cortices, and this can lead to adenoma or carcinoma formation.

The main symptoms of the disease include severe alopecia, pruritus (itchiness), polydipsia (excessive drinking), aggressive behaviour, swollen or enlarged vulva/prostate tissue, and muscular atrophy. Adrenocortical hyperplasia may cause malignant tumours to develop; in this case the condition is often life threatening.

Current treatment options include surgery to remove the affected gland, inhibition of the release of GnRH using melatonin, and desensitisation of the pituitary gland using Lupron Depot injections, again stopping the production of GnRH. Unfortunately, surgery has limitations in that only the left gland can be removed safely because ferrets with both adrenal glands absent are likely to develop Addison’s disease, and the right gland is extremely close to the vena cava. Melatonin and Lupron only work to relieve the symptoms; they do not remove the tumour (although Lupron may shrink it).

Recently, subcutaneous deslorelin implants manufactured by Virbac have been legally marketed in the UK. Over the period of about 8 months, the implant releases hormones which antagonise the release of GnRHs, removing the stimulus for the overproduction of sex hormones by the adrenal glands. This treatment is multifunctional because not only can it be used to reduce the effects or prevent the onset of adrenal disease, but it can even be used as an alternative to neutering, saving the ferret the pain and risk associated with surgery. The implants are not yet approved in the USA, but with further research they may have great potential in the treatment of this highly prevalent condition.

 

References:

www.gwexotics.com/wccms-resources/7/f/d/c/0e35972c-9c16-11e0-a685-0050568626ea.pdf

http://www.ferretclub.org.au/showcontent.toy?cid=101506

http://www.greendale.co.uk/adrenal_disease_ferrets.html

http://www.drsfostersmith.com/pic/article.cfm?aid=1983

http://www.avianandexoticvets.com/gallery/articles/deslorelin-implants

 

Picture credits:

http://www.pet-care-portal.com/images/ferret.jpg